Gall bladder mucosal epithelial hyalinosis

Research Services

Research Services

Welcome to the Comparative Pathology Laboratory, where our team of experts stands ready to support your research endeavors. We provide a comprehensive range of services with the mission to aid investigators using animal models of disease and interventional therapeutics. Services are available for intramural (University of California) and extramural investigators. Our vast array of services include:

•           Necropsy services for research study animals, including gross dissection of target tissues, high-quality photo documentation, histological processing, pathology interpretation and training of investigators in animal necropsy.

•           Pathology services including histopathology evaluation and interpretation of tissues, scoring and semi-quantitative data analysis, and photomicroscopy, conducted by board-certified veterinary pathologists (American College of Veterinary Pathologists) experienced in multiple areas including geropathology and aging, infectious diseases, models of immunotherapy and humanized mice (including CAR T cells), genetic therapy (including AAV), oncology, degenerative diseases, among many others.

•           Morphological phenotyping of rodents (including novel genetic engineered mouse (GEM) models) and other non-rodent experimental animals, including full necropsy, organ weight, clinical pathology, and histopathology interpretation.

•           Pre-study consultation services covering experimental design and planning, animal modeling and optimal sample collection strategies.

•           Generation of publication-ready figures, text, and graphics to enhance the scientific quality and dissemination of research findings.

•           Clinical pathology services including hematology, clinical chemistry panels, serology, molecular diagnosis (PCR), parasitology and microbiology, all validated for mouse and other research species. Subsequent processing of these specimens and downstream assays are also available.

For further information on how we can support your project, please reach out to us at cpl-projects@ucdavis.edu. We look forward to collaborating with you.

Digital analysis
Example of digital image analysis for between-group comparisons.

Recent publications:

  1. Olstad JK, Imai DM, Keesler RK, Reader R, Morrison JH, Roberts JA, Capitanio JP, Didier ES, Kuroda MJ, Ikeno Y, Ladiges W. Benefits of adapting the rodent Geropathology Grading Platform for use in non-human primates. Geroscience. Submitted.
     
  2. Hilton HG, Rubinstein ND, Janki P, Ireland AT, Bernstein N, Fong NL, Wright KM, Smith M, Finkle D, Martin-McNulty B, Roy M, Imai DM, Jojic V, Buffenstein R. Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity. 2019. PLOS Biology. https://doi.org/10.1371/journal.pbio.3000528
     
  3. Foley, J, Allan N, Pesapane R, Johnson A, Woods L, Brignolo L, Luce A, Clifford DL, Imai DM. Disease and pathological conditions of an endangered rodent, Microtus californicus scirpensis, in a captive-rearing facility andin the wild. J Zoo Wildl Med. 2019. In revision.
     
  4. Snyder JM, Snider T, Ciol MA, Wilkinson JE, Imai DM, Casey KM, Vilches-Moure JG, Pettan-Brewer C, Pillai SPS, Carrasco SE, Salimi S, Ladiges W. Validation of a geropathology system for aging mouse studies.Geroscience. 2019. doi: 10.1007/s11357-019-00088-w.
     
  5. Brownlee R, Imai DM, Coleman D, Abdelrazek S, Soto E. Experimental infection of mice with Veronaea botryosamodels human phaeohyphomycosis. Comp Med. 2019. doi: 10.30802/AALAS-CM-18-000151
     
  6. Hodzic E, ImaiDM, Escobar E. Generality of Post-Antimicrobial treatment persistence of Borrelia burgdorferistrains N40 and B31 in genetically susceptible and resistant mouse strains. Infect Immun.2019. doi: 10.1128/IAI.00442-19
     
  7. Oz-Levi D, Olender T, Bar-Joseph I, ZhuY, Marek-Yagel D, Alkelai A, Ruzzo EK, Han Y, Vos E, Tatarskyy P, Reznik-Wolf H, Milgrom R, Weiss B, Pode-Shakked B, Schvimer M, Barshack I, Hartman C, Shapiro R, Shamir R, Imai DM, Barozzi I, Osterwalder M, Coleman-Derr D, Dickel DE, Nord AS, Afzal V, Lammerts van Bueren K, Barnes RM, Visel A, Black BL, Mayhew CN, Kuhar MF, Pitstick A, Tekman M, Stanescu HC, Wells JM, Kleta R, de Laat W, Goldstein DB, Pras E, Pennacchio LA, Lancet D, Anikster Y. Noncoding deletions expose a novel gene critical for intestinal function. Nature. Accepted.
     
  8. Moore BA, Leonard BC, Sebbag L, Edwards SG, Cooper A, Imai DM, Straiton E, Santos L, Reilly C, Griffey SM, Bower L, Clary D, Mason J, Roux MJ, Meziane H, Herault Y, International Mouse Phenotyping Consortium, McKerlie C, Flenniken AM, Nutter L, Berberovic Z, Owen C, Newbigging S, Adissu H, Eskandarian M, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gallegos JJ, Seavitt JR, Heaney JD, Beaudet AL, Dickinson ME, Justice MJ, Philip V, Kumar V, Svenson KL, Braun RE, Wells S, Cater H, Stewart M, Clementson-Mobbs S, Joynson R, Gao X, Suzuki T, Wakana S, Smedley D, Seong JK, Tocchini-Valentini G, Moore M, Fletcher C, Karp N, Ramirez-Solis R, White JK, de Angelis MH, Wurst W, Thomasy SM, Flicek P, Parkinson H, Brown S, Meehan TF, Nishina PM, Murray SA, Krebs MP, Mallon AM, Lloyd K, Murphy CJ, Moshiri A. Identification of genes required for eye development by high-throughput screening of mouse knockouts.Commun Biol.2018; 1:236. doi:10.1038/s42003-018-0226-0
     
  9. Casey KM,Johnson AL, Hunrath MN, Fraser JK, McCowan NC, Wasson K, Doty RA, Griffey SM, Imai DM. Proliferative typhlocolitis with multinucleated giant cells: A non-pathogen-specific enteropathy in immunodeficient sentinel mice. Vet Pathol. 2018; 56: 157-68.
     
  10. Harris TR, KodaniS, Rand A, Yang J, Imai DM, Hwang SH, Hammock BD. Celecoxib exacerbates liver fibrosis in a carbon tetrachloride-induced model. Mol Pharmacol. 2018; 94: 834-841
     
  11. Moore BA, Roux MJ, Sebbag L, Cooper A, Edwards SG, Leonard BC, Imai DM, Griffey S, Bower L, Clary D, Lloyd KC, Herault Y, Thomasy SM, Murphy CJ, Moshiri A. A population study of common ocular abnormalities in C57BL/6N Rd8mice. Invest Ophthalmol Vis Sci. 2018; 59: 2252-2261.
     
  12. Imai DM, Pesapane R, Conroy C, Alarcon CN, Allan, N, Okino RA, Fung J, Murphy BG, Verstraete FJM, Foley J. Apical elongation of molar teeth in captive Microtus voles. Vet Pathol.2018; Jan 1:300985818758469. doi: 10.1177/0300985818758469